产品货号：
Z35274
中文名称：
p57Kip2/CDKN1C抗体
英文名称：
Anti-p57Kip2/CDKN1C Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-p57Kip2/CDKN1C Antibody |
| 指标别名 | BWCR;BWS;CDKN1C;KIP2;p57;p57Kip2;WBS |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ICC/IF,IP |
| 基因名称 | CDKN1C |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human p57 Kip2 |
| 实际分子量 | 30KD/57KD |
| 成分 | Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | p27 Kip1 is a member of the Cip/Kip family of cyclin-dependent kinase inhibitors.Like its relatives,p57 Kip2 and p21 Waf1/Cip1,the ability to enforce the G1 restriction point is derived from its inhibitory binding to CDK2/cyclin E and other CDK/cyclin complexes.Expression levels of p27 are upregulated in quiescent cells and in cells treated with cAMP or other negative cell cycle regulators.Downregulation of p27 can be induced by treatment with interleukin-2 or other mitogens;this involves phosphorylation of p27 and its degradation by the ubiquitin-proteasome pathway (1-4).p57 Kip2 (Cyclin-dependent kinase inhibitor 1C) functions as a tumor suppressor.Mutations of p57 Kip2 have been associated with numerous human malignancies as well as Beckwith–Wiedemann syndrome (BWS),characterized by an increased risk of childhood cancer. |
| Uniprot ID | P49918 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Mouse IgG (ZN1928) for Western blot,and HRP Conjugated anti-Mouse IgG Super Vision Assay Kit (ZN1866) for IHC(P) and ICC. |
| 推荐稀释比 | Western blot (WB) 1:100～400 Immunohistochemistry in paraffin section (IHC) 1:10～50 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:10～50 ImmunoPrecipitation (IP) 1:20 |
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